Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC0448
Trial ID NCT03614858
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD20 CAR-T cells
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleCD19/CD22-targeted Chimeric Antigen Receptor Engineered T Cell (CART) in B-Cell Acute Lymphoblastic Leukemia.
Year2017
CountryChina
Company sponsorShanghai Unicar-Therapy Bio-medicine Technology Co., Ltd
Other ID(s)UnicarTherapy201807

Clinical Result

Cohort1: Tandem CAR-T
Administration route intravenous infusion
Dosage 1~20E6 cells/kg
Pts 49
Age Child, Adult, Older_Adult
Outcome 47/49(CR)
Adverse reactions 9/49(cytokine release syndrome)
References DOI: 10.1182/blood-2021-152927
Cohort2: Sequential CAR-T
Administration route None
Pts 13
Age Child, Adult, Older_Adult
Outcome 9/13(CR)
Adverse reactions 3/13(cytokine release syndrome)
References DOI: 10.1182/blood-2021-152927

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