Basic Information

Gene symbol TRBC1 Synonyms BV05S1J2.2, TCRB, TCRBC1 Type of gene other
Description T cell receptor beta constant 1

GTO ID GTC0445
Trial ID NCT03590574
Disease Angioimmunoblastic T-Cell Lymphoma | Anaplastic Large Cell Lymphoma | T-Cell Non-Hodgkin's Lymphoma | Peripheral T-Cell Lymphoma
Altered gene TRBC1
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment AUTO4
PhasePhase1|Phase2
Recruitment statusRecruiting
TitlePhase I/II Study Evaluating AUTO4 in Patients With TRBC1 Positive T Cell Lymphoma
Year2018
CountryUnited States
Company sponsorAutolus Limited
Other ID(s)AUTO4-TL1|2017-001965-26

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 25E6 cells, 75E6 cells, 225E6 cells, 450E6 cells
Donor type Autologous
Pts 12
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 5/12(CR); 3/12(PR)
Adverse reactions 6/12(CRS); no ICANS or DLTs

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