Basic Information

Gene symbol MUC1 Synonyms ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3, EMA, H23AG, KL-6, MAM6, MCD, MCKD, MCKD1, MUC-1, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description mucin 1, cell surface associated

GTO ID GTC0437
Trial ID NCT03525782
Disease Lung Malignant Neoplasm | Lung Non-Small Cell Carcinoma
Altered gene MUC1
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment MUC-1 CAR-T cells
PhasePhase1|Phase2
Recruitment statusUnknown
TitleAnti-MUC1 CAR T Cells and PD-1 Knockout Engineered T Cells for NSCLC
Year2018
CountryChina
Company sponsorThe First Affiliated Hospital of Guangdong Pharmaceutical University
Other ID(s)2018-006
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route None
Dosage 2.5E6 cells/kg
Pts 20
Age Adult, Older_Adult
Outcome 11/20(SD); 9/20(PD)
Adverse reactions no any CAR-T-related severe events
References : Phase I clinical trial of PD-1 knockout anti-MUC1 CAR-T cells in the treatment of patients with non-small cell lung cancer

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