Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC0431
Trial ID NCT03502577
Disease Plasma Cell Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment BCMA CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusSuspended
TitleBCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or Persistent Multiple Myeloma
Year2018
CountryUnited States
Company sponsorFred Hutchinson Cancer Center
Other ID(s)9952|NCI-2018-00514|9952|RG9218033

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E7 cells
Pts 6
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 6/6(PR)
Adverse reactions 4/6(neutropenic fever); 4/6(neurotoxicity)
References DOI: 10.1182/blood-2019-129405

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