Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0426
Trial ID NCT03483688
Disease B-Cell Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhasePhase1
Recruitment statusCompleted
TitleA PhaseⅠb Study Evaluating Safety and Efficacy of C-CAR011 Treatment in B- NHL Subjects
Year2018
CountryChina
Company sponsorPeking Union Medical College Hospital
Other ID(s)CBMG-C2017007
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 0.5~5E6 cells/kg
Pts 6
Age Adult, Older_Adult
Outcome 3/6(CR). The ORR at Week 4, 12 and Month 6, 12 were 50%(3/6), 50%(3/6), 16.7%(1/6) and 16.7%(1/6), respectively.
Adverse reactions 6/6(hematological toxicities); 4/6(cytokine release syndrome); 1/6(neurotoxicity )

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