Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0424
Trial ID NCT03467256
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Co-treatment Tocilizumab|Cytarabine|Etoposide|Dexamethasone
Generation2nd
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleCD19 T-CAR for Treatment of Children and Young Adults With r/r B-ALL
Year2018
CountryRussian Federation
Company sponsorFederal Research Institute of Pediatric Hematology, Oncology and Immunology
Other ID(s)NCPHOI-2018-01

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E5 cells/kg, 5E5 cells/kg, 1E6 cells/kg, 3E6 cells/kg
Donor type Autologous
Pts 31
Age Child, Adult
Lymph depletion Yes
Outcome 24/27(CR)
Adverse reactions 2/31(cytokine release syndrome); 4/31(immune effector cell-associated neurotoxicity syndrome)
References PMID: 34893603

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