Basic Information

Gene symbol PROM1 Synonyms AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description prominin 1

Gene symbol EGFR Synonyms ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description epidermal growth factor receptor

Gene symbol EPHA2 Synonyms ARCC2, CTPA, CTPP1, CTRCT6, ECK Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description EPH receptor A2


Gene symbol ERBB2 Synonyms CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description erb-b2 receptor tyrosine kinase 2

Gene symbol IL13RA2 Synonyms CD213A2, CT19, IL-13R, IL13BP Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description interleukin 13 receptor subunit alpha 2

GTO ID GTC0418
Trial ID NCT03423992
Disease Brain Glioma
Altered gene EGFR|IL13RA2|HER2|EPHA2|CD133|GD2
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitlePersonalized Chimeric Antigen Receptor T Cell Immunotherapy for Patients With Recurrent Malignant Gliomas
Year2018
CountryChina
Company sponsorXuanwu Hospital, Beijing
Other ID(s)Xuanwu hospital
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E6 cells/kg
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/3(SD); 2/3(PD). overall survival ranging from 86 to 181 days.
Adverse reactions 2/3(grade 2 cytokine release syndrome)
References PMID: 34235085

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