Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0407
Trial ID NCT03389035
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
PhasePhase1|Phase2
Recruitment statusCompleted
TitleTransposon-manipulated Allogeneic CARCIK-CD19 Cells in Pediatric and Adult Patients With r/r ALL Post HSCT
Year2017
CountryItaly
Company sponsorFondazione Matilde Tettamanti Menotti De Marchi Onlus
Other ID(s)FT01CARCIK
Vector information
VectorSleeping Beauty system

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E6 cells/kg, 3E6 cells/kg, 7.5E6 cells/kg, 1.5E6 cells/kg
Donor type Allogeneic
Pts 16
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 61.50%(ORR); 6/7(CR)
References PMID: 32780725

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