Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0398
Trial ID NCT03344705
Disease Hematologic Cancer
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment IM19CAR-T
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitleSafety and Efficacy Evaluation of IM19 Cells
Year2017
CountryChina
Company sponsorBeijing Immunochina Medical Science & Technology Co., Ltd.
Other ID(s)YMCART201701
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ

Clinical Result

Cohort 1
Administration route infusion
Dosage 3E6 cells/kg
Donor type Autologous
Pts 5
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 2/5(CR); 1/5(PR); 1/5(SD)
Adverse reactions no any CAR-T-related severe events
References PMID: 30622321

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