Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC0392
Trial ID NCT03318861
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment KITE-585
PhasePhase1
Recruitment statusTerminated
TitleStudy to Evaluate the Safety and Efficacy of KITE-585 in Participants With Relapsed/Refractory Multiple Myeloma
Year2017
CountryUnited States
Company sponsorKite, A Gilead Company
Other ID(s)KITE-585-501

Clinical Result

Cohort1: dose escalation_dose level 1
Administration route intravenous infusion
Dosage 3E7 cells
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 2/3(All-cause Mortality)
Cohort2: dose escalation_dose level 2
Administration route intravenous infusion
Dosage 1E8 cells
Donor type Autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 4/4(All-cause Mortality)
Cohort3: dose escalation_dose level 3
Administration route intravenous infusion
Dosage 3E8 cells
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 3/3(All-cause Mortality); 1/3(General disorders; Respiratory, thoracic and mediastinal disorders)
Cohort4: dose escalation_dose level 4
Administration route intravenous infusion
Dosage 1E9 cells
Donor type Autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 3/4(All-cause Mortality)
Cohort5: dose expansion_dose level 1
Administration route intravenous infusion
Dosage 3E7 cells
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 3/3(All-cause Mortality)

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