Basic Information


Gene symbol tk

Gene symbol IL12A Synonyms CLMF, IL-12A, NFSK, NKSF1, P35 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description interleukin 12A

Gene symbol IL12B Synonyms CLMF, CLMF2, IL-12B, IMD28, IMD29, NKSF, NKSF2 Type of gene protein-coding
Description interleukin 12B



GTO ID GTC0387
Trial ID NCT03281382
Disease Pancreatic Cancer
Altered gene E1|IL-12A|IL-12B|yCD|SR39|tk
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment AdV5-yCD/mutTKSR39rep-hIL12
PhasePhase1
Recruitment statusCompleted
TitlePHASE 1 TRIAL OF ONCOLYTIC ADENOVIRUS-MEDIATED CYTOTOXIC AND IL-12 GENE THERAPY IN COMBINATION WITH CHEMOTHERAPY FOR THE TREATMENT OF METASTATIC PANCREATIC CANCER
Year2017
CountryUnited States
Company sponsorHenry Ford Health System
Other ID(s)11260
Vector information
Vectoradenovirus
ConstructAd5- yCD/ mut TK SR39 rep -hIL-12
Vector typeadenoviral serotype 5 (Ad5) vector
Transgene/Inserted geneIL12A; IL12B; yCD; SR39; HSV-TK
Regulatory elementhuman cytomegalovirus (CMV) promoter; SV40 polyadenylation sites
Vector production methodThe adenovirus was generated by calcium phosphate precipitation of the pCA14-yCD/mutTKSR39 and pBGH8k-hIL-12 plasmids linearized with PvuI and ClaI, respectively. The precipitated DNA was co-transfected in AD293 cells and then purified (Adenopure; Puresyn, Malvern, PA, USA).

Clinical Result

Cohort1: dose level 1
Administration route intratumoral injection
Dosage 1E11 vp
Pts 3
Age Adult, Older_Adult
Outcome 2/3(PD); 1/3(cannot be determined based on CT every 2-3 months)
References PMID: 33575474
Cohort2: dose level 2
Administration route intratumoral injection
Dosage 3E11 vp
Pts 3
Age Adult, Older_Adult
Outcome 1/3(PD); 2/3(SD)
References PMID: 33575474
Cohort3: dose level 3
Administration route intratumoral injection
Dosage 1E12 vp
Pts 6
Age Adult, Older_Adult
Outcome 3/6(PD); 3/6(SD)
References PMID: 33575474

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