Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC0381
Trial ID NCT03207178
Disease Diffuse Large B-Cell Lymphoma
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD20 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusUnknown
TitleSequential Infusion of Anti-CD19 and Anti-CD20 CAR-T Cells Against Relapsed and Refractory B-cell Lymphoma
Year2017
CountryChina
Company sponsorShanghai Longyao Biotechnology Inc., Ltd.
Other ID(s)LYCT-1701
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route infusion
Dosage 1~5E6 cells/kg
Donor type Autologous
Pts 21
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 11/21(CR); 6/21(PR); 1/21(SD); 3/21(PD)
Adverse reactions 6/21(cytokine release syndrome)
References PMID: 32608579

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