Basic Information

Gene symbol CD33 Synonyms CD33rSiglec, SIGLEC-3, SIGLEC3, p67 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description CD33 molecule

GTO ID GTC0370
Trial ID NCT03126864
Disease Acute Myeloid Leukemia
Altered gene CD33
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD33 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusTerminated
TitleStudy of Adoptive Cellular Therapy Using Autologous T Cells Transduced With Lentivirus to Express a CD33 Specific Chimeric Antigen Receptor in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia
Year2017
CountryUnited States
Company sponsorM.D. Anderson Cancer Center
Other ID(s)2016-0341|NCI-2018-01167
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Additional featureHER1t

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.3E6 cells/kg
Donor type Autologous
Pts 3
Age Child, Adult, Older_Adult
Adverse reactions 2/3(cytokine release syndrome); 1/3(immune effector cell-associated neurotoxicity syndrome)

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