Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0367
Trial ID NCT03103971
Disease Acute Lymphoblastic Leukemia | B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment JCAR021
PhasePhase1
Recruitment statusActive, Not Recruiting
TitleHuJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia
Year2017
CountryUnited States
Company sponsorFred Hutchinson Cancer Center
Other ID(s)9364|NCI-2017-00421|9364|RG9217000

Clinical Result

Cohort 1
Administration route None
Dosage 7E5 cells/kg, 2E6 cells/kg, 7E6 cells/kg
Pts 23
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 12/23(CR); 5/23(PR)
Adverse reactions 1/23(cytokine release syndrome); 10/23(immune effector cell-associated neurotoxicity syndrome)
References DOI: 10.1182/blood-2022-157826

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