Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC0366
Trial ID NCT03097770
Disease Non-Hodgkin's Lymphoma | Diffuse Large B-Cell Lymphoma
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment TanCAR7 T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusCompleted
TitleTreatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20
Year2017
CountryChina
Company sponsorChinese PLA General Hospital
Other ID(s)TanCAR7
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneCD19 single-chain variable fragment (scFv); CD20 scFv; 4-1BB; CD3 zeta
Vector production methodThe TanCAR7 construct was generated by linking the CD19 single-chain variable fragment (scFv) derived from the FMC63 monoclonal antibody (mAb) and the CD20 scFv derived from the Leu-16 mAb18 in frame with the hinge and transmembrane domains of CD8 and the cytoplasmic domains of 4-1BB and CD3 zeta.

Clinical Result

Cohort1: dose level 1_NHL
Administration route infusion
Dosage 0.5~8E6 cells/kg
Donor type Autologous|Allogeneic
Pts 87
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 61/87(CR); 7/87(PR)
Adverse reactions 9/87(cytokine release syndrome); 2/87(CAR T cell-related encephalopathy syndrome)
References PMID: 34272481
Cohort2: dose level 2_NHL
Administration route infusion
Dosage 1~8E6 cells/kg
Donor type Autologous|Allogeneic
Pts 28
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 20/28(CR); 2/28(PR); 10/28(PD)
Adverse reactions 4/28(cytokine release syndrome)
References PMID: 34272481
Cohort3: DLBCL
Administration route infusion
Donor type Autologous|Allogeneic
Pts 56
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 40/56(CR); 5/56(PR); 11/56(PD)
References PMID: 34272481

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