Basic Information

Gene symbol TNFRSF17 Synonyms BCM, BCMA, CD269, TNFRSF13A Type of gene protein-coding
Description TNF receptor superfamily member 17

GTO ID GTC0363
Trial ID NCT03090659
Disease Multiple Myeloma
Altered gene BCMA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment LCAR-B38M
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleLCAR-B38M Cells in Treating Relapsed/Refractory (R/R) Multiple Myeloma
Year2017
CountryChina
Company sponsorNanjing Legend Biotech Co.
Other ID(s)LCAR-B38M

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 5E5~5E6 cells/kg
Pts 74
Age Adult, Older_Adult
Outcome 54/74(CR).The median progression-free survival:18.0 months; The median duration of response:23.3 months
Adverse reactions 45/74(Grade ≥ 3 AEs); 7/74(Grade ≥ 3 cytokine release syndrome)

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