Basic Information

Gene symbol PDCD1 Synonyms CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description programmed cell death 1

GTO ID GTC0362
Trial ID NCT03081715
Disease Esophageal Cancer
Altered gene PDCD1
Therapeutic/Target gene Target gene
TherapyGene editing
Treatment PD-1 Knockout T cells
PhaseNot Applicable
Recruitment statusCompleted
TitleSafety and Activity of Programmed Cell Death-1 Knockout Engineered T Cells in Patients With Previously Treated Advanced Esophageal Squamous Cell Carcinoma: An Open-label, Single-arm Phase 1 Study
Year2017
CountryChina
Company sponsorHangzhou Cancer Hospital
Other ID(s)HangzhouCH07

Clinical Result

Cohort 1
Administration route infusion
Dosage 1E10 cells
Donor type autologous
Pts 21
Age Adult, Older_Adult
Outcome 6/17(SD); 11/17(PD). The disease control rate was 35% (6/17), and the median overall survival was 127 days (95% CI 45–209). During the trial, 10 cancer progression-related deaths occurred.
Adverse reactions No grade 3 or 4 adverse events were observed in the study.
References DOI: 10.1200/JCO.2018.36.15_suppl.3054

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