Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0354
Trial ID NCT03029338
Disease B-Cell Non-Hodgkin's Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CNCT19|inaticabtagene autoleucel
Location approved China
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleCD19 CAR T Cells in Patients With Relapsed or Refractory CD19 Positive B-cell Lymphoma
Year2017
CountryChina
Company sponsorInstitute of Hematology & Blood Diseases Hospital
Other ID(s)XH-CD19CART-002
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneAnti-CD19 scFv combined to human 4-1BB/CD3-ζ costimulatory signaling components

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1.87~56E6
Donor type Autologous|Allogeneic
Pts 16
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 6/16(CR) at 3 months
Adverse reactions 1/16(CAR T cell-related encephalopathy syndrome)
References DOI: 10.1182/blood-2022-167104

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