Basic Information

Gene symbol BCL2L12 Synonyms None Type of gene protein-coding
Description BCL2 like 12

GTO ID GTC0353
Trial ID NCT03020017
Disease Gliosarcoma
Altered gene BCL2L12
Therapeutic/Target gene Target gene
TherapysiRNA
Treatment NU-0129
Co-treatment Laboratory Biomarker Analysis|Pharmacological Study
PhasePhase1
Recruitment statusCompleted
TitleA Phase 0 First-In-Human Study Using NU-0129: A Spherical Nucleic Acid (SNA) Gold Nanoparticle Targeting BCL2L12 in Recurrent Glioblastoma Multiforme or Gliosarcoma Patients
Year2017
CountryUnited States
Company sponsorNorthwestern University
Other ID(s)NU 16C01|STU00203790|P30CA060553|NCI-2016-02007
Vector information
VectorGold Nanoparticles

Clinical Result

Cohort 1
Administration route intravenous injection
Pts 8
Age Adult, Older_Adult
Outcome Number of Patients With Adverse Events: Experienced any AE:8; Experienced an AE related to NU-01289:4; Experienced any SAE:1; Experienced an SAE related to NU-0129:0
Adverse reactions 0/8(All-cause mortality); 1/8(Nervous system disorders)
References PMID: 33692132 | 35406387

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