Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

Gene symbol MS4A1 Synonyms B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7 Type of gene protein-coding
Description membrane spanning 4-domains A1

GTO ID GTC0352
Trial ID NCT03019055
Disease Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma | B-Cell Lymphoma | Non-Hodgkin's Lymphoma
Altered gene CD19|CD20
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19/CD20 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleStudy of CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell
Year2017
CountryUnited States
Company sponsorMedical College of Wisconsin
Other ID(s)PRO00028724
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneanti-cluster of differentiation 20 (CD20) single chain variable fragment (scFv); CD3ζ; co-stimulatory domain 4-1BB

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E5 cells/kg, 2.5E5 cells/kg, 7.5E5 cells/kg, 2.5E6 cells/kg
Donor type Autologous
Pts 22
Age Adult, Older_Adult
Outcome 14/22(CR); 4/22(PR)
Adverse reactions 1/22(cytokine release syndrome); 3/22(neurotoxicity)
References PMID: 33020647

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