Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0346
Trial ID NCT02992743
Disease Liposarcoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment Letetresgene autoleucel|GSK3377794|Lete-cel
HLAHLA-A*02:01|HLA-A*02:05|HLA-A*02:06
PhasePhase2
Recruitment statusCompleted
TitleA Pilot Study of NY-ESO-1c259T Cells in Subjects With Advanced Myxoid/ Round Cell Liposarcoma
Year2016
CountryUnited States
Company sponsorGlaxoSmithKline
Other ID(s)208469|ADP-0011-007

Clinical Result

Cohort1: Reduced Lymphodepletion Dose
Administration route infusion
Pts 13
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 2/10(PR); 8/10(SD)
Adverse reactions 5/13(All-cause mortality); 5/13(Blood and lymphatic system disorders; Cardiac disorders; Gastrointestinal disorders; Immune system disorders; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Respiratory, thoracic and mediastinal disorders)
Cohort2: Standard Lymphodepletion Dose
Administration route infusion
Pts 10
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 4/10(PR); 1/10(PD); 5/10(SD)
Adverse reactions 7/10(General disorders; Immune system disorders; Immune system disorders; Neoplasms benign, malignant and unspecified, incl cysts and polyps; Respiratory, thoracic and mediastinal disorders; Skin and subcutaneous tissue disorders)

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