Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0341
Trial ID NCT02968472
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment 4SCAR-T cells
Generation4th
PhasePhase1
Recruitment statusUnknown
TitleA Phase I Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Leukemia
Year2015
CountryChina
Company sponsorThe First People's Hospital of Yunnan
Other ID(s)LXUN
Vector information
Vectorother
ConstructscFv-CD28-CD27-CD3ζ
Additional featureiCasp9

Clinical Result

Cohort 1
Administration route None
Donor type Autologous
Pts 17
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 7/17(cytokine release syndrome)
References PMID: 32772769

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