Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0338
Trial ID NCT02935257
Disease Small Lymphocytic Lymphoma | B-Cell Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment AUTO1|Obecabtagene autoleucel|obe-cel
Generation2nd
PhasePhase1
Recruitment statusRecruiting
TitleImmunotherapy for High Risk/Relapsed CD19+ Acute Lymphoblastic Leukaemia, B-cell Non-Hodgkin's Lymphoma (B-NHL) and Chronic Lymphocytic Leukaemia (CLL)/ Small Lymphocytic Lymphoma (SLL) Using CAR T-cells to Target CD19 (ALLCAR19)
Year2017
CountryUnited Kingdom
Company sponsorUniversity College, London
Other ID(s)UCL/16/0530
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route None
Dosage 10E6 cells, 100E6 cells, 410E6 cells
Donor type Autologous
Pts 20
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 17/20(CR,1 cmonth).6 months event-free survival 68.3% (42.4%-84.4%); 12 months event-free survival:48.3% (23.1%-69.7%)
Adverse reactions 3/20(Grade 3 neurotoxicity)
References PMID: 34464155

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