Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0337
Trial ID NCT02924753
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitleThe Safety and Efficacy of CART-19 Cells in B-cell Acute Lymphoblastic Leukemia (B-ALL).
Year2016
CountryChina
Company sponsorHenan Cancer Hospital
Other ID(s)HenanCH080
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ

Clinical Result

Cohort 1
Administration route infusion
Dosage 1~4E6 cells/kg
Donor type Autologous
Pts 29
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 26/29(CR); 2/29(PD)
Adverse reactions 6/29(cytokine release syndrome)

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