Basic Information

Gene symbol HA Synonyms None Type of gene protein-coding
Description haemagglutinin

GTO ID GTC0336
Trial ID NCT02918006
Disease Influenza
Altered gene HA
Therapeutic/Target gene Therapeutic gene
TherapydsRNA
Treatment VXA-A1.1|Ad-HA-dsRNA
PhasePhase2
Recruitment statusCompleted
TitlePhase 2 Randomized, Controlled, Human Influenza A (H1N1) Challenge Study Following Administration of an Oral H1N1 HA Adenoviral-Vector Based Seasonal Influenza Vaccine and dsRNA Adjuvant to Healthy Adult Volunteers
Year2016
CountryUnited States
Company sponsorVaxart
Other ID(s)VXA-CHAL-201
Vector information
Vectoradenovirus
ConstructAd-HA-dsRNA
Vector typereplication-defective adenovirus serotype 5 (Ad5) vector
Transgene/Inserted genehaemagglutinin (A/CA/04/2009) transgene
Regulatory elementa cytomegalovirus promoter; a molecular dsRNA hairpin driven by a separate promoter

Clinical Result

Cohort1: VXA-A1.1
Administration route oral|intramuscular injection
Pts 71
Age Adult
Outcome Number of Subjects With Influenza-like Clinical Illness and Laboratory Confirmed Infection Post Challenge With a Homologous A Strain Influenza Virus:17(29.3%)
Adverse reactions No serious clinical adverse events
References PMID: 31978354
Cohort2: Fluzone
Administration route oral|intramuscular injection
Pts 72
Age Adult
Outcome Number of Subjects With Influenza-like Clinical Illness and Laboratory Confirmed Infection Post Challenge With a Homologous A Strain Influenza Virus:19(35.2%)
Adverse reactions No serious clinical adverse events
References PMID: 31978354
Cohort3: Placebo
Administration route oral|intramuscular injection
Pts 36
Age Adult
Outcome Number of Subjects With Influenza-like Clinical Illness and Laboratory Confirmed Infection Post Challenge With a Homologous A Strain Influenza Virus:15(48.4%)
Adverse reactions No serious clinical adverse events
References PMID: 31978354

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