Basic Information

Gene symbol TNFRSF8 Synonyms CD30, D1S166E, Ki-1 Type of gene protein-coding
Description TNF receptor superfamily member 8

GTO ID GTC0335
Trial ID NCT02917083
Disease Non-Hodgkin's Lymphoma | Hodgkin's Lymphoma
Altered gene CD30
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD30 CAR-T cells
PhasePhase1
Recruitment statusRecruiting
TitleCD30 CAR T Cells, Relapsed CD30 Expressing Lymphoma (RELY-30)
Year2017
CountryUnited States
Company sponsorBaylor College of Medicine
Other ID(s)H-37966, RELY-30|RELY-30
Vector information
Vectorretrovirus
Vector typegammaretrovirus vector
Transgene/Inserted geneCD30.CAR

Clinical Result

Cohort 1
Administration route infusion
Dosage 2E7 cells/m^2, 1E8 cells/m^2, 2E8 cells/m^2
Donor type Autologous
Pts 17
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 8/17(CR); 3/17(PR); 2/17(SD); 4/17(PD)
References PMID: 32701411

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