Basic Information

Gene symbol tk


GTO ID GTC0333
Trial ID NCT02894944
Disease Pancreatic Cancer
Altered gene yCD|tk
Therapeutic/Target gene Therapeutic gene
TherapyDNA oncolytic virus
Treatment Theragene
PhasePhase1
Recruitment statusCompleted
TitleClinical Trial Phase I for Evaluation of Tolerability and Safety of Replication-competent Adenovirus-mediated Double Suicide Gene Therapy in Combination With Chemotherapy for the Locally Advanced Pancreatic Cancer
Year2016
CountryKorea,Republic of
Company sponsorSeoul National University Hospital
Other ID(s)SNUBH-IMGPB-2016-02
Vector information
Vectoradenovirus

Clinical Result

Cohort1: dose level 1
Administration route intratumoral injection
Dosage 1E11 vp/mL
Pts 3
Age Adult, Older_Adult
Outcome 3/3(SD)
References PMID: 32084409
Cohort2: dose level 2
Administration route intratumoral injection
Dosage 3E11 vp/mL
Pts 3
Age Adult, Older_Adult
Outcome 1/3(PR)
Adverse reactions 1/3(Pain of injections)
References PMID: 32084409
Cohort3: dose level 3
Administration route intratumoral injection
Dosage 1E12 vp/mL
Pts 3
Age Adult, Older_Adult
Outcome 3/3(SD)
Adverse reactions 1/3(Fever)
References PMID: 32084409

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