Basic Information

Gene symbol E7 Synonyms None Type of gene protein-coding
Description transforming protein E7

GTO ID GTC0328
Trial ID NCT02858310
Disease Vulva Squamous Cell Carcinoma | Head and Neck Squamous Cell Carcinoma | Cervical Squamous Cell Carcinoma | Cervical Adenocarcinoma | Anal Squamous Cell Carcinoma
Altered gene E7
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment HPV-16 E7 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleA Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated Cancers
Year2016
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)160154|16-C-0154
Vector information
Vectorretrovirus
Vector typeMSGV1 gamma-retrovirus vector
Transgene/Inserted geneE7 TCR

Clinical Result

Cohort1: Vulvar SCC
Administration route infusion
Dosage 0.01~1.2E11 cells
Donor type autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/1(PR)
Adverse reactions no TCR related AEs
References PMID: 33558725
Cohort2: Head and Neck SCC
Administration route infusion
Dosage 0.01~1.2E11 cells
Donor type autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/4(PR); 2/4(SD)
Adverse reactions no TCR related AEs
References PMID: 33558725
Cohort3: Cervical SCC
Administration route infusion
Dosage 0.01~1.2E11 cells
Donor type autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 3/4(PR); 1/4(SD)
Adverse reactions no TCR related AEs
References PMID: 33558725
Cohort4: Cervical Adenocarcinoma
Administration route infusion
Dosage 0.01~1.2E11 cells
Donor type autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/1(SD)
Adverse reactions no TCR related AEs
References PMID: 33558725
Cohort5: Anal SCC
Administration route infusion
Dosage 0.01~1.2E11 cells
Donor type autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/2(PR)
Adverse reactions no TCR related AEs
References PMID: 33558725

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