Basic Information

Gene symbol tk

GTO ID GTC0325
Trial ID NCT02831933
Disease Lung Non-Squamous Non-Small Cell Carcinoma | Lung Squamous Cell Carcinoma | Uveal Melanoma
Altered gene tk
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment Adv-HSV-tk
Co-treatment Valacyclovir|radiation therapy|nivolumab
PhasePhase2
Recruitment statusTerminated
TitlePhase II Window of Opportunity Trial of Stereotactic Body Radiation Therapy and In Situ Gene Therapy Followed by Nivolumab in Metastatic Squamous or Non-Squamous Non-Small Cell Lung Carcinoma and Metastatic Uveal Melanoma
Year2016
CountryUnited States
Company sponsorThe Methodist Hospital Research Institute
Other ID(s)Pro00014976
Vector information
Vectoradenovirus
ConstructADV/HSV-tk
Vector typereplication-defective recombinant adenovirus vector
Transgene/Inserted geneherpes simplex virus (HSV) thymidine kinase gene

Clinical Result

Cohort 1
Administration route intratumoral injection
Dosage 5E11 vp/2 mL
Pts 11
Age Adult, Older_Adult
Outcome 11/11(PD)
Adverse reactions 1/11(All-cause mortality); 4/11(Blood and lymphatic system disorders; Cardiac disorders; General disorders; Metabolism and nutrition disorders; Respiratory, thoracic and mediastinal disorders)

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