Basic Information

Gene symbol CCR5 Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22 Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description C-C motif chemokine receptor 5

GTO ID GTC0318
Trial ID NCT02797470
Disease HIV Infection
Altered gene CCR5
Therapeutic/Target gene Target gene
TherapyshRNA
Treatment CCR5 shRNA/TRIM5alpha/TAR decoy LV CD34+ cells
Co-treatment Carmustine|Cytarabine|Etoposide|Melphalan
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleA Phase I Study of Stem Cell Gene Therapy for HIV Mediated by Lentivector Transduced, Pre-Selected CD34+ Cells
Year2016
CountryUnited States
Company sponsorAIDS Malignancy Consortium
Other ID(s)AMC-097|NCI-2015-01745|9933|AMC 097|097|AMC-097|U01CA121947
Vector information
Vectorlentivirus
Transgene/Inserted geneCCR5 shRNA; TRIM5alpha; TAR decoy

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 11
Age Adult, Older_Adult
Adverse reactions 5/11(All-cause mortality); 2/11(platelet count decreased; blood bilirubin increased)

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