Basic Information

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC0311
Trial ID NCT02770820
Disease Acute Myeloid Leukemia
Altered gene WT1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment WT1 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusTerminated
TitlePhase I/II Study of Autologous (Central Memory/Naïve) CD8+ T Cells That Have Been Transduced to Express a WT1-Specific T Cell Receptor for Treatment of AML
Year2016
CountryUnited States
Company sponsorFred Hutchinson Cancer Center
Other ID(s)9296|NCI-2016-00042|9296|P01CA018029|P30CA015704|RG9216011

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 7
Age Child, Adult, Older_Adult
Lymph depletion No
Adverse reactions 1/7(All-cause mortality)

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