Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0309
Trial ID NCT02746952
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment UCAR-T19|S68587
PhasePhase1
Recruitment statusCompleted
TitleDose Escalation Study of UCART19 in Adult Patients With Relapsed / Refractory B-cell Acute Lymphoblastic Leukaemia
Year2016
CountryFrance
Company sponsorInstitut de Recherches Internationales Servier
Other ID(s)CL1-68587-002|2016-000296-24
Vector information
Vectorlentivirus

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 6E6 cells, 6~8E7 cells, 1.8~2.4E8 cells
Donor type Allogeneic
Pts 25
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 6/25(cytokine release syndrome); 1/25(neurological toxicity); 7/25(infections); 4/25(cytopenia)
References PMID: 36228643

Relationship Graph

Overview of Knowledge Graph