Basic Information

Gene symbol IFNB1 Synonyms IFB, IFF, IFN-beta, IFNB Type of gene protein-coding
Gene perturbation-related omics dataset PertOrg
Description interferon beta 1

GTO ID GTC0305
Trial ID NCT02727764
Disease Rheumatoid Arthritis | Osteoarthritis
Altered gene IFNB
Therapeutic/Target gene Therapeutic gene
TherapyGene transfer
Treatment ART-I02|AAV5.NF-kB.IFN-β
PhasePhase1
Recruitment statusUnknown
TitleA Single Dose Clinical Trial to Study the Safety of ART-I02 in Patients With Arthritis
Year2016
CountryNetherlands
Company sponsorArthrogen
Other ID(s)ART-I02-001-NL
Vector information
Vectoradeno-associated virus
ConstructAAV5.NF-kB.IFN-β
Vector typerecombinant adeno-associated virus serotype 2/5 (rAAV2/5) vector
Transgene/Inserted genehIFN-b gene
Regulatory elementa promoter responsive to the pro-inflammatory nuclear factor κB (NF-κB)
Vector production methodART-I02 was produced using polyethylenimine (PEIpro™) mediated transient transfection of HEK293T/17 cells with pART-I02 vector plasmid and pDP5-Kan3 helper/packaging plasmid, a derivative of pDP5 with the ampicillin resistance gene replaced by the kanamycin resistance gene.

Clinical Result

Cohort1: dose level 1
Administration route intraarticular injection
Dosage 1.2E12 vg/ CMC joint, 1.2E12 vg/ MCP joint, 0.6E12 vg/ PIP joint or 0.3E12 vg/ DIP joint single intra-articular injection
Age Adult, Older_Adult
Adverse reactions No serious clinical adverse events
References PMID: 34626797
Cohort2: dose level 2
Administration route intraarticular injection
Dosage 1.2E12 vg/ CMC joint, 1.2E13 vg/ MCP joint, 0.6E13 vg/ PIP joint or 0.3E13 vg/ DIP joint single intra-articular injection
Age Adult, Older_Adult
Adverse reactions No serious clinical adverse events
References PMID: 34626797
Cohort3: dose level 3
Administration route intraarticular injection
Dosage 1.2E12 vg/ CMC joint, 1.2E13 vg/ MCP joint, 0.6E13 vg/ PIP joint or 0.3E13 vg/ DIP joint or maximum Tolerated Dose (MTD) single intra-articular injection
Age Adult, Older_Adult
Adverse reactions No serious clinical adverse events
References PMID: 34626797

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