Basic Information

Gene symbol TNFRSF8 Synonyms CD30, D1S166E, Ki-1 Type of gene protein-coding
Description TNF receptor superfamily member 8

GTO ID GTC0295
Trial ID NCT02690545
Disease Lymphoma | Non-Hodgkin's Lymphoma | Lymphoproliferative Syndrome
Altered gene CD30
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD30 CAR-T cells
PhasePhase1|Phase2
Recruitment statusRecruiting
TitleStudy of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL
Year2016
CountryUnited States
Company sponsorUNC Lineberger Comprehensive Cancer Center
Other ID(s)LCCC 1532-ATL

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E8 cells/m^2, 2E8 cells/m^2
Donor type Autologous
Pts 27
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 18/27(CR); 1/27(PR); 2/27(SD); 6/27(PD)
References PMID: 34666347

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