Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0292
Trial ID NCT02659943
Disease Non-Hodgkin's Lymphoma | B-Cell Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleT Cells Expressing a Fully-human AntiCD19 Chimeric Antigen Receptor for Treating B-cell Malignancies
Year2016
CountryUnited States
Company sponsorNational Cancer Institute (NCI)
Other ID(s)160054|16-C-0054
Vector information
Vectorlentivirus
ConstructscFv-CD28-CD3ζ
Vector typeLSIN, lentivirus self-inactivating

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 0.66E6 cells
Donor type Autologous
Pts 3
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/3(CR); 0/3(PR); 0/3(SD); 0/3(PD)
Adverse reactions 3/3(Nervous system disorders, Vascular disorders)
References PMID: 31959992
Cohort2: dose level 2
Administration route intravenous infusion
Dosage 0.66E6 cells foll/by 2E6 cells
Donor type Autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/2(PR); 1/2(PD)
Adverse reactions 1/2(Respiratory, thoracic and mediastinal disorders; Vascular disorders)
References PMID: 31959992
Cohort3: dose level 3
Administration route intravenous infusion
Dosage 0.66E6 cells foll/by 6E6 cells
Donor type Autologous
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/1(CR); 0/1(PR); 0/1(SD); 0/1(PD)
Adverse reactions 1/1(Endocrine disorders)
References PMID: 31959992
Cohort4: dose level 4
Administration route intravenous infusion
Dosage 2E6 cells
Donor type Autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/4(CR); 0/4(PR); 0/4(SD); 0/4(PD)
Adverse reactions 3/4(Infections and infestations; Investigations; Metabolism and nutrition disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)
References PMID: 31959992
Cohort5: dose level 5
Administration route intravenous infusion
Dosage 2E6 cells foll/by 6E6 cells
Donor type Autologous
Pts 2
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 1/2(PR); 1/2(SD)
Adverse reactions 1/2(Blood and lymphatic system disorders)
References PMID: 31959992
Cohort6: dose level 6
Administration route intravenous infusion
Dosage 6E6 cells
Donor type Autologous
Pts 9
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 0/9(CR); 0/9(PR); 0/9(SD); 0/9(PD)
Adverse reactions 8/9(Cardiac disorders; Gastrointestinal disorders; General disorders; Infections and infestations; Musculoskeletal and connective tissue disorders; Nervous system disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)
References PMID: 31959992

Relationship Graph

Overview of Knowledge Graph