Basic Information

Gene symbol MLANA Synonyms MART-1, MART1 Type of gene protein-coding
Description melan-A

GTO ID GTC0289
Trial ID NCT02654821
Disease Metastatic Melanoma
Altered gene MART-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment MAGE-1 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusUnknown
TitleMulticenter Phase I/IIa Study Using T-cell Receptor Gene Therapy in Metastatic Melanoma
Year2016
CountryNetherlands
Company sponsorThe Netherlands Cancer Institute
Other ID(s)M11TCR
Vector information
Vectorretrovirus
Vector typeMP71 retroviral vector
Transgene/Inserted gene1D3HMCys TCR

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.05~4.56E9 cells
Donor type autologous
Pts 12
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 1/12(death); 6/12(CRS); 10/12(Dermatitis); 3/12(Uveitis); 4/12(Hearing loss)
References PMID: 35865122

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