Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0285
Trial ID NCT02650986
Disease Fallopian Tube Cancer | Melanoma | Ovarian Carcinoma | Synovial Sarcoma | Peritoneal Carcinoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusActive, Not Recruiting
TitleA Phase I/IIa Study of TGFβ Blockade in TCR-Engineered T-Cell Cancer Immunotherapy in Patients With Advanced Malignancies
Year2015
CountryUnited States
Company sponsorRoswell Park Cancer Institute
Other ID(s)I 258514|NCI-2015-02080|I 258514|P30CA016056|R01CA164333

Clinical Result

Cohort1: dose level 1
Administration route intravenous infusion
Dosage 1E7 cells
Donor type autologous
Pts 3
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 2/3(All-cause mortality); 1/3(Eye disorders; Gastrointestinal disorders; Gastrointestinal disorders; )
Cohort2: dose level 2
Administration route intravenous infusion
Dosage 1E8 cells
Donor type autologous
Pts 6
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 4/6(All-cause mortality); 3/6(Immune system disorders; Metabolism and nutrition disorders; Neoplasms benign, malignant and unspecified, incl cysts and polyps; Nervous system disorders)

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