Basic Information

Gene symbol MAGEA10 Synonyms CT1.10, MAGE10 Type of gene protein-coding
Description MAGE family member A10

GTO ID GTC0274
Trial ID NCT02592577
Disease Lung Non-Small Cell Carcinoma | Carcinoma
Altered gene MAGE-A10
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment ADP-A2M10
HLAHLA-A*02:01|HLA-A*02:06
PhasePhase1
Recruitment statusCompleted
TitleA Phase I Dose Escalation Open Label Clinical Trial Evaluating the Safety and Efficacy of MAGE A10c796 T in Subjects With Stage IIIb or Stage IV Non-Small Cell Lung Cancer (NSCLC)
Year2015
CountryUnited States
Company sponsorAdaptimmune
Other ID(s)ADP 0022-003
Vector information
Vectorlentivirus
Transgene/Inserted genehigh-affinity melanoma-associated antigen (MAGE)-A10-specific T-cell receptor

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.1~15E9 cells
Donor type autologous
Pts 11
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 5/11(SD); 5/11(PD)
Adverse reactions 3/11(CRS); 1/11(pancytopenia); 1/11(aplastic anemia); 1/11(delirium); 1/11(lightheadedness)
References PMID: 35086946

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