Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0273
Trial ID NCT02588612
Disease Neoplasm
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment Letetresgene autoleucel|GSK3377794|Lete-cel
HLAHLA-A*02
PhasePhase1
Recruitment statusCompleted
TitleA Pilot Open-Label Clinical Trial Evaluating the Safety and Efficacy of Autologous T Cells Expressing Enhanced TCRs Specific for NY-ESO-1 in Subjects With Stage IIIb or Stage IV Non-Small Cell Lung Cancer (NSCLC)
Year2015
CountryUnited States
Company sponsorGlaxoSmithKline
Other ID(s)208749|ADP-0011-004|2016-002517-21

Clinical Result

Cohort 1
Administration route infusion
Donor type autologous
Pts 5
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 2/5(ORR)
Adverse reactions 4/10(All-cause mortality); 4/10(Blood and lymphatic system disorders; Gastrointestinal disorders; Immune system disorders; Infections and infestations; Nervous system disorders; Respiratory, thoracic and mediastinal disorders; Skin and subcutaneous tissue disorders; Vascular disorders)

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