Basic Information

Gene symbol CD22 Synonyms SIGLEC-2, SIGLEC2 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description CD22 molecule

GTO ID GTC0272
Trial ID NCT02588456
Disease B-Cell Acute Lymphoblastic Leukemia
Altered gene CD22
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD22 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusTerminated
TitlePilot Study of Autologous Anti-CD22 Chimeric Antigen Receptor Redirected T Cells In Patients With Chemotherapy Resistant Or Refractory Acute Lymphoblastic Leukemia
Year2015
CountryUnited States
Company sponsorUniversity of Pennsylvania
Other ID(s)UPCC 31415, 822967
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneTCRζ; 4-1BB; anti-CD22 scFv

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage <50kg: 1~10E6 cells/kg, >50kg and adults: 5E8 cells
Donor type Autologous
Pts 8
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 4/8(CR)
Adverse reactions 1/8(cytokine release syndrome)
References PMID: 33888899

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