Basic Information

Gene symbol PROM1 Synonyms AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas
Description prominin 1

GTO ID GTC0263
Trial ID NCT02541370
Disease Brain Cancer | Breast Cancer | Liver Cancer | Pancreatic Cancer | Acute Myeloid Leukemia | Colorectal Cancer
Altered gene CD133
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD133 CAR-T cells
Generation2nd
PhasePhase1|Phase2
Recruitment statusCompleted
TitleTreatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133
Year2015
CountryChina
Company sponsorChinese PLA General Hospital
Other ID(s)s2015-080-03
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Vector production methodCAR T cells were produced by directly adding the anti-CD3 monoclonal antibody OKT3 to whole PBMCs suspended in culture medium containing interleukin (IL)-2.

Clinical Result

Cohort 1
Administration route infusion
Dosage 0.5E6~2E6 cells/kg
Donor type Autologous
Pts 21
Age Adult, Older_Adult
Lymph depletion No
Outcome 1/21(PR); 14/21(SD). The median OS was 12 months (95% CI, 9.3-15.3 months) and the median PFS was 6.8 months (95% CI, 4.3-8.4 months).
Adverse reactions 2/21(Anemia), 4/21(Hyperbilirubinemia )
References PMID: 33312759 | 29900044

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