Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0260
Trial ID NCT02535364
Disease Acute Lymphoblastic Leukemia
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment JCAR015
PhasePhase2
Recruitment statusTerminated
TitleStudy Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia (B-ALL)
Year2015
CountryUnited States
Company sponsorJuno Therapeutics, a Subsidiary of Celgene
Other ID(s)15001|JCAR015

Clinical Result

Cohort 1
Administration route intravenous infusion
Donor type Autologous
Pts 82
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 45.45%(ORR)
Adverse reactions 24/38(All-cause mortality); 23/38(Blood and lymphatic system disorders; Cardiac disorders; Gastrointestinal disorders; General disorders; Hepatobiliary disorders; Immune system disorders; Infections and infestations; Nervous system disorders)

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