Basic Information

Gene symbol CD19 Synonyms B4, CVID3 Type of gene protein-coding
Description CD19 molecule

GTO ID GTC0257
Trial ID NCT02529813
Disease Chronic Lymphocytic Leukemia | Acute Biphenotypic Leukemia | Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Small Lymphocytic Lymphoma
Altered gene CD19
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CD19 CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusCompleted
TitleCD19-Specific T-cells in Treating Patients With Advanced Lymphoid Malignancies
Year2015
CountryUnited States
Company sponsorM.D. Anderson Cancer Center
Other ID(s)2013-1018|NCI-2015-01492|20152145|1159157|2013-1018

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E5~E9 cells/kg
Donor type Autologous
Pts 26
Age Child, Adult, Older_Adult
Lymph depletion Yes
Adverse reactions no any CAR-T-related severe events
References PMID: 32983475

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