Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0249
Trial ID NCT02457650
Disease Melanoma | Breast Cancer | Neuroblastoma | Esophagus Sarcoma | Ovarian Cancer | Synovial Sarcoma | Multiple Myeloma | Bladder Carcinoma | Lung Cancer
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment NY-ESO-1 TCR-T cells
HLAHLA-A2
PhasePhase1
Recruitment statusUnknown
TitlePhase I Study of Malignancies That Express NY-ESO-1 With T Cell Receptor-transduced T Cells Targeting NY-ESO-1
Year2015
CountryChina
Company sponsorShenzhen Second People's Hospital
Other ID(s)201504002
Vector information
Vectorlentivirus|retrovirus
Transgene/Inserted genenucleic acid sequences encoding an HLA-A2 restricted TCR recognizing NY-ESO-1:157-165 epitope

Clinical Result

Cohort 1
Administration route infusion
Dosage 1.67~10.6E9 cells
Donor type autologous
Pts 4
Age Child, Adult, Older_Adult
Lymph depletion Yes
Outcome 1/4(SD); 1/4(PR); 1/4(PD)
Adverse reactions 3/4(Fever); 4/4(anemia); 4/4(White blood cell decrease)
References PMID: 30546433

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