Detail

Basic Information Clinical Results Relationship Graph

Basic Information

Gene symbol	STAT3	Synonyms	ADMIO, ADMIO1, APRF, HIES	Type of gene	protein-coding
Chromosome	17	Map location	17q21.2	dbXrefs
Gene perturbation-related omics dataset	PerturbAtlas \| PertOrg
Description	signal transducer and activator of transcription 3

GTO ID	GTC0245
Trial ID	NCT02417753
Disease	Gastrointestinal Allergy \| Ovarian Cancer
Altered gene	STAT3
Therapeutic/Target gene	Target gene
Therapy	ASO
Treatment	ISIS 481464\|Danvatirsen\|ISIS-STAT3rx\|AZD9150\|IONIS-STAT3-2.5Rx
Phase	Phase2
Recruitment status	Terminated
Title	A Pilot Study of AZD9150, a STAT3 Antisense Oligonucleotide in Malignant Ascites
Year	2015
Country	United States
Company sponsor	National Cancer Institute (NCI)
Other ID(s)	150112\|15-C-0112

Vector information

Vector	No vector was used

Clinical Result

Cohort1: dose level 1

Administration route	intravenous infusion
Pts	1
Age	Adult, Older_Adult
Adverse reactions	1/1(All-cause mortality); 1/1(Cardiac disorders; Gastrointestinal disorders; General disorders; Musculoskeletal and connective tissue disorders; Vascular disorders)

Cohort2: dose level 2

Administration route	intravenous infusion
Dosage	AZD9150, Cycle 1: days 1, 3, 5, 8, 15 and 22 of a 28 day cycle. Cycle 2 and beyond Days 1, 8, 15 and 22 of a 28 day cycle
Pts	1
Age	Adult, Older_Adult
Adverse reactions	1/1(All-cause mortality); 1/1(Cardiac disorders; Gastrointestinal disorders; General disorders; Musculoskeletal and connective tissue disorders; Vascular disorders)

Relationship Graph

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