Basic Information

Gene symbol WT1 Synonyms AWT1, GUD, NPHS4, WAGR, WIT-2, WT-1, WT33 Type of gene protein-coding
Gene perturbation-related omics dataset PerturbAtlas | PertOrg
Description WT1 transcription factor

GTO ID GTC0242
Trial ID NCT02408016
Disease Lung Non-Small Cell Carcinoma | Malignant Mesothelioma
Altered gene WT1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment WT1 TCR-T cells
HLAHLA-A*02:01
PhasePhase1|Phase2
Recruitment statusTerminated
TitlePhase I/II Study in WT1-Expressing Non-small Cell Lung Cancer and Mesothelioma, Comparing Cellular Adoptive Immunotherapy With Polyclonal Autologous Central Memory to Naïve CD8+ T Cells That Have Been Transduced to Express a WT1-Specific T-Cell Receptor
Year2015
CountryUnited States
Company sponsorFred Hutchinson Cancer Research Center
Other ID(s)2727.00|NCI-2015-00329|2727|2727.00|P30CA015704

Clinical Result

Cohort1: infusion cyclophosphamide on days 11 and 12
Administration route infusion
Donor type autologous
Pts 6
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 6/6(All-cause mortality)
Cohort2: infusion cyclophosphamide on days -3 and -2
Administration route infusion
Donor type autologous
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 2/4(All-cause mortality)

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