Basic Information

Gene symbol PDGFB Synonyms IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis Type of gene protein-coding
Description platelet derived growth factor subunit B

GTO ID GTC0238
Trial ID NCT02387957
Disease Age-Related Macular Degeneration
Altered gene PDGFB
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment E10030|Fovista|anti-PDGF BB
Co-treatment bevacizumab
PhasePhase2
Recruitment statusTerminated
TitleA 24 Month Phase 2a Open Label, Randomized Study of Avastin, Lucentis, or Eylea (Anti-VEGF Therapy) Administered in Combination With Fovista (Anti-PDGF BB Pegylated Aptamer)
Year2015
CountryUnited States
Company sponsorOphthotech Corporation
Other ID(s)OPH1006

Clinical Result

Cohort1: Fovista_bevacizumab
Administration route intravitreal injection
Dosage 1.5 mg
Pts 21
Age Adult, Older_Adult
Adverse reactions 3/21(Infections and infestations)
Cohort2: Fovista_ranibizumab
Administration route intravitreal injection
Dosage 1.5 mg
Pts 21
Age Adult, Older_Adult
Adverse reactions 3/21(Eye disorders; Injury, poisoning and procedural complications; Respiratory, thoracic and mediastinal disorders)
Cohort3: Fovista_aflibercept
Administration route intravitreal injection
Dosage 1.5 mg
Pts 21
Age Adult, Older_Adult
Adverse reactions 5/21(Cardiac disorders; General disorders; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified, incl cysts and polyps; Renal and urinary disorders)

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