Basic Information

Gene symbol CTAG1B Synonyms CTAG, ESO1, CT6.1, CTAG1, LAGE-2, LAGE2B, NY-ESO-1 Type of gene protein-coding
Description cancer/testis antigen 1B

GTO ID GTC0236
Trial ID NCT02366546
Disease Synovial Sarcoma | Breast Cancer | Salivary Gland Cancer | Melanoma | Ovarian Cancer | Myxoid Liposarcoma
Altered gene NY-ESO-1
Therapeutic/Target gene Target gene
TherapyTCR-T cell
Treatment TBI-1301
HLAHLA-A*02:01|HLA-A*02:06
PhasePhase1
Recruitment statusUnknown
TitleMulti-center, Investigator Initiated Phase 1 Study of NY-ESO-1 Specific TCR Gene Transferred T Lymphocytes With Solid Tumors
Year2015
CountryJapan
Company sponsorMie University
Other ID(s)1301-01
Vector information
Vectorretrovirus
Transgene/Inserted geneDNA encoding TCR-α and TCR-β chains specific for NY-ESO-1157-165 and HLA-A*02:01 (MS3-NY-ESO-1-siTCR); interfering RNA constructs that specifically downregulate endogenous TCR

Clinical Result

Cohort1: Synovial sarcoma
Administration route infusion
Dosage 0.5~5E9 cells
Donor type Allogeneic
Pts 4
Age Adult, Older_Adult
Lymph depletion Yes
Adverse reactions 3/9(CRS); 1/9(lung injury)
References PMID: 35768164
Cohort2: Breast cancer
Administration route infusion
Dosage 0.5~5E9 cells
Donor type Allogeneic
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 35768164
Cohort3: Malignant salivary tumor
Administration route infusion
Dosage 0.5~5E9 cells
Donor type Allogeneic
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 35768164
Cohort4: Melanoma
Administration route infusion
Dosage 0.5~5E9 cells
Donor type Allogeneic
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 35768164
Cohort5: Ovarian cancer
Administration route infusion
Dosage 0.5~5E9 cells
Donor type Allogeneic
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 35768164
Cohort6: Myxoid liposarcoma
Administration route infusion
Dosage 0.5~5E9 cells
Donor type Allogeneic
Pts 1
Age Adult, Older_Adult
Lymph depletion Yes
References PMID: 35768164

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