Basic Information

Gene symbol CEACAM5 Synonyms CD66e, CEA Type of gene protein-coding
Description CEA cell adhesion molecule 5

GTO ID GTC0234
Trial ID NCT02349724
Disease Pancreatic Cancer | Lung Cancer | Stomach Cancer | Breast Cancer | Colorectal Cancer
Altered gene CEA
Therapeutic/Target gene Target gene
TherapyCAR-T cell
Treatment CEA CAR-T cells
Generation2nd
PhasePhase1
Recruitment statusUnknown
TitleA Clinical Research of CAR T Cells Targeting CEA Positive Cancer
Year2014
CountryChina
Company sponsorSouthwest Hospital, China
Other ID(s)TMMU-BTC-002
Vector information
Vectorlentivirus
ConstructscFv-4-1BB-CD3ζ
Transgene/Inserted geneBW431/26 scFv; IgG4 hinge; CD28 transmembrane domain; CD28; CD3ζ
Vector production methodLentivirus was produced and purified from the supernatant of 293T cells with transfection of the pCDH lentiviral plasmid, envelope plasmid PMD2.G, packaging plasmid (pMDLg/pRRE), and plasmid-producing Rev regulatory protein (pRSV-Rev).

Clinical Result

Cohort 1
Administration route intravenous infusion
Dosage 1E5~E8 cells/kg
Donor type Autologous
Pts 10
Age Adult, Older_Adult
Lymph depletion Yes
Outcome 7/10(SD); 2/10(PD)
Adverse reactions no any CAR-T-related severe events
References PMID: 28366766

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