Basic Information

Gene symbol PDGFB Synonyms IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis Type of gene protein-coding
Description platelet derived growth factor subunit B

GTO ID GTC0217
Trial ID NCT02214628
Disease Age-Related Macular Degeneration
Altered gene PDGFB
Therapeutic/Target gene Target gene
TherapyAptamer
Treatment E10030|Fovista|anti-PDGF BB
Co-treatment anti-VEGF
PhasePhase2
Recruitment statusTerminated
TitleA 24 Month Phase 2A Open Label Safety Study of Fovista (Anti-PDGF-BB Pegylated Aptamer) Regiment Administered in Combination With Avastin, Eylea, or Lucentis) During the Induction and Maintenance Phase of Therapy
Year2014
CountryUnited States
Company sponsorOphthotech Corporation
Other ID(s)OPH1005

Clinical Result

Cohort1: Anti-VEGF Simultaneous Regimen
Administration route None
Pts 38
Age Adult, Older_Adult
Adverse reactions 2/63(All-cause mortality); 19/63(Blood and lymphatic system disorders; Cardiac disorders; Endocrine disorders; Eye disorders; Gastrointestinal disorders; General disorders; Hepatobiliary disorders; Immune system disorders; Infections and infestations; Injury, poisoning and procedural complications; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified, incl cysts and polyps; Nervous system disorders; Renal and urinary disorders; Respiratory, thoracic and mediastinal disorders; Vascular disorders)
Cohort2: Anti-VEGF Pre-Treatment Regimen
Administration route None
Age Adult, Older_Adult
Adverse reactions 2/38(All-cause mortality); 8/38(Cardiac disorders; Gastrointestinal disorders; Hepatobiliary disorders; Infections and infestations; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified, incl cysts and polyps; Respiratory, thoracic and mediastinal disorders; Vascular disorders)

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